Try Your Hand at 4 Sample USMLE Step 3 Practice Questions

You’re rounding the third and final corner of your USMLE exam experience, and now is no time to let your guard down. The USMLE Step 3 exam is typically found to be easier than its first two counterparts, however, you won’t pass on just sheer knowledge alone, you’ll need to hone your timing, skills, and knowledge through practice questions. We’ve pulled four highly rated questions from the BoardVitals USMLE Step 3 Practice Question Bank. Can you answer them correctly?

How did you do? Whether you aced the quiz or missed them all, you need to make sure you’re putting your best foot forward on this final component to the USMLE series. The USMLE Step 3 exam is given over two non-consecutive days. It is divided into six blocks of no more than 40 questions, each given over a 60 minute period. The USMLE Step 3 questions are notoriously longer and more detailed than its two other counterparts, and thus requires a more efficient use of times by test-takers. Taking practice quizzes and timed practice questions will help you be more cognizant of your time constraint.

The USMLE Step 3 exam is broken down into the following sections:

  • Medical Knowledge/Scientific Concepts 18-22%
  • Patient Care: Diagnosis 40-45%
    • History/Physical Examination
    • Laboratory/Diagnostic Studies
    • Diagnosis
  • Prognosis/Outcome 20-25%
  • Patient Care: Management 75-80%
    • Health Maintenance/Disease Prevention
    • Pharmacotherapy
    • Clinical Interventions
    • Mixed Management
    • Surveillance for Disease Recurrence
  • Communication and Professionalism 8-12%
  • Systems-based Practice/Patient Safety and Practice-based Learning 22-27%

BoardVitals offers a USMLE Step 3 Question Bank with more than 1100 DIFFICULT practice questions targeted to the exam. Each question comes with detailed explanations and rationales to act as mini-lectures providing a more comprehensive understanding of the topics at hand. Want more free practice? Click here for a free trial.


  • shalena 12 months

    He cannot have a liver transplant unless he stops drinking. In this scenario, he is still drinking

    • Hi there, Thanks for commenting! Nice observation, although the question doesn’t mention that the patient is currently drinking, it just says he has alcoholic cirrhosis. Asking about and testing for current drinking habits could result in a different outcome, correct. I’ve removed the photo (one that we’ve added to make the quiz more interesting, but doesn’t necessarily affect the question), in case that causes confusion for future users. Good luck studying!