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Brain biopsy

The patient undergoes a biopsy of the brain which shows enlarged, distorted astrocytes with eosinophilic inclusions found within the hemispheric white matter. Electron microscopy is presented below which shows granulocytic deposits in the astrocytic processes.

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A. Schedule a family meeting to discuss the diagnosis, as no further workup is required
B. Perform mutational analysis for exon 1, position 249 of glial fibrillary acidic protein cDNA
C. Schedule a follow-up with the patient in one year with no further testing required
D. MRI of the brain
E. Neuro-metabolic investigations 

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